Probing Early Misfolding Events in Prion Protein Mutants by NMR Spectroscopy

The post-translational conversion of the ubiquitously expressed cellular form of the prion protein, PrP(C), into its misfolded and pathogenic isoform, known as prion or PrP(Sc), plays a key role in prion diseases. These maladies are denoted transmissible spongiform encephalopathies (TSEs) and affect...

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Detalles Bibliográficos
Autores principales: Giachin, Gabriele, Biljan, Ivana, Ilc, Gregor, Plavec, Janez, Legname, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270549/
https://www.ncbi.nlm.nih.gov/pubmed/23966072
http://dx.doi.org/10.3390/molecules18089451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270549/
https://www.ncbi.nlm.nih.gov/pubmed/23966072
http://dx.doi.org/10.3390/molecules18089451

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