Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl(2)-Induced Neurotoxicity in Differentiated PC12 Cells

A series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methox...

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Autores principales: Wang, Penglong, Zhang, Honggui, Chu, Fuhao, Xu, Xin, Lin, Jinxuan, Chen, Chunxiao, Li, Guoliang, Cheng, Yatao, Wang, Lin, Li, Qiang, Zhang, Yuzhong, Lei, Haimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270565/
https://www.ncbi.nlm.nih.gov/pubmed/24145795
http://dx.doi.org/10.3390/molecules181013027
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author Wang, Penglong
Zhang, Honggui
Chu, Fuhao
Xu, Xin
Lin, Jinxuan
Chen, Chunxiao
Li, Guoliang
Cheng, Yatao
Wang, Lin
Li, Qiang
Zhang, Yuzhong
Lei, Haimin
author_facet Wang, Penglong
Zhang, Honggui
Chu, Fuhao
Xu, Xin
Lin, Jinxuan
Chen, Chunxiao
Li, Guoliang
Cheng, Yatao
Wang, Lin
Li, Qiang
Zhang, Yuzhong
Lei, Haimin
author_sort Wang, Penglong
collection PubMed
description A series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (4a) displayed promising protective effect on the proliferation of the injured PC12 cells (EC(50) = 4.249 µM). Structure-activity relationships are briefly discussed.
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spelling pubmed-62705652018-12-18 Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl(2)-Induced Neurotoxicity in Differentiated PC12 Cells Wang, Penglong Zhang, Honggui Chu, Fuhao Xu, Xin Lin, Jinxuan Chen, Chunxiao Li, Guoliang Cheng, Yatao Wang, Lin Li, Qiang Zhang, Yuzhong Lei, Haimin Molecules Article A series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (4a) displayed promising protective effect on the proliferation of the injured PC12 cells (EC(50) = 4.249 µM). Structure-activity relationships are briefly discussed. MDPI 2013-10-18 /pmc/articles/PMC6270565/ /pubmed/24145795 http://dx.doi.org/10.3390/molecules181013027 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wang, Penglong
Zhang, Honggui
Chu, Fuhao
Xu, Xin
Lin, Jinxuan
Chen, Chunxiao
Li, Guoliang
Cheng, Yatao
Wang, Lin
Li, Qiang
Zhang, Yuzhong
Lei, Haimin
Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl(2)-Induced Neurotoxicity in Differentiated PC12 Cells
title Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl(2)-Induced Neurotoxicity in Differentiated PC12 Cells
title_full Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl(2)-Induced Neurotoxicity in Differentiated PC12 Cells
title_fullStr Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl(2)-Induced Neurotoxicity in Differentiated PC12 Cells
title_full_unstemmed Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl(2)-Induced Neurotoxicity in Differentiated PC12 Cells
title_short Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl(2)-Induced Neurotoxicity in Differentiated PC12 Cells
title_sort synthesis and protective effect of new ligustrazine-benzoic acid derivatives against cocl(2)-induced neurotoxicity in differentiated pc12 cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270565/
https://www.ncbi.nlm.nih.gov/pubmed/24145795
http://dx.doi.org/10.3390/molecules181013027
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