7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer’s Disease Treatment — Synthesis, Biological Evaluation and Molecular Modeling Studies

A structural series of 7-MEOTA-adamantylamine thioureas was designed, synthesized and evaluated as inhibitors of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE). The compounds were prepared based on the multi-target-directed ligand strategy with different linker lengths (n...

Descripción completa

Detalles Bibliográficos
Autores principales: Spilovska, Katarina, Korabecny, Jan, Kral, Jan, Horova, Anna, Musilek, Kamil, Soukup, Ondrej, Drtinova, Lucie, Gazova, Zuzana, Siposova, Katarina, Kuca, Kamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270602/
https://www.ncbi.nlm.nih.gov/pubmed/23429378
http://dx.doi.org/10.3390/molecules18022397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270602/
https://www.ncbi.nlm.nih.gov/pubmed/23429378
http://dx.doi.org/10.3390/molecules18022397

Ejemplares similares