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7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer’s Disease Treatment — Synthesis, Biological Evaluation and Molecular Modeling Studies

A structural series of 7-MEOTA-adamantylamine thioureas was designed, synthesized and evaluated as inhibitors of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE). The compounds were prepared based on the multi-target-directed ligand strategy with different linker lengths (n...

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Detalles Bibliográficos
Autores principales:	Spilovska, Katarina, Korabecny, Jan, Kral, Jan, Horova, Anna, Musilek, Kamil, Soukup, Ondrej, Drtinova, Lucie, Gazova, Zuzana, Siposova, Katarina, Kuca, Kamil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270602/ https://www.ncbi.nlm.nih.gov/pubmed/23429378 http://dx.doi.org/10.3390/molecules18022397

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