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An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs
An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270617/ https://www.ncbi.nlm.nih.gov/pubmed/24029747 http://dx.doi.org/10.3390/molecules180911144 |
| _version_ | 1783376740164304896 |
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| author | Yang, Xiu-Yan Xia, Guang-Qiang Wang, Xiao-Kui Zheng, Zhi-Bing Zhao, Dong-Mei Zhao, Guo-Ming Li, Song |
| author_facet | Yang, Xiu-Yan Xia, Guang-Qiang Wang, Xiao-Kui Zheng, Zhi-Bing Zhao, Dong-Mei Zhao, Guo-Ming Li, Song |
| author_sort | Yang, Xiu-Yan |
| collection | PubMed |
| description | An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates. |
| format | Online Article Text |
| id | pubmed-6270617 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62706172018-12-18 An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs Yang, Xiu-Yan Xia, Guang-Qiang Wang, Xiao-Kui Zheng, Zhi-Bing Zhao, Dong-Mei Zhao, Guo-Ming Li, Song Molecules Article An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates. MDPI 2013-09-11 /pmc/articles/PMC6270617/ /pubmed/24029747 http://dx.doi.org/10.3390/molecules180911144 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| spellingShingle | Article Yang, Xiu-Yan Xia, Guang-Qiang Wang, Xiao-Kui Zheng, Zhi-Bing Zhao, Dong-Mei Zhao, Guo-Ming Li, Song An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs |
| title | An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs |
| title_full | An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs |
| title_fullStr | An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs |
| title_full_unstemmed | An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs |
| title_short | An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs |
| title_sort | efficient synthesis of enantiopure (r)-heteroarylpyrimidine analogs |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270617/ https://www.ncbi.nlm.nih.gov/pubmed/24029747 http://dx.doi.org/10.3390/molecules180911144 |
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