Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors

New derivatives of uridine which contain a β-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1–4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were not active against Candida albicans and Aspergil...

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Autores principales: Paszkowska, Jadwiga, Kral, Katarzyna, Bieg, Tadeusz, Nawrot, Urszula, Szeja, Wiesław, Wandzik, Ilona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270623/
https://www.ncbi.nlm.nih.gov/pubmed/23884133
http://dx.doi.org/10.3390/molecules18078018
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author Paszkowska, Jadwiga
Kral, Katarzyna
Bieg, Tadeusz
Nawrot, Urszula
Szeja, Wiesław
Wandzik, Ilona
author_facet Paszkowska, Jadwiga
Kral, Katarzyna
Bieg, Tadeusz
Nawrot, Urszula
Szeja, Wiesław
Wandzik, Ilona
author_sort Paszkowska, Jadwiga
collection PubMed
description New derivatives of uridine which contain a β-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1–4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were not active against Candida albicans and Aspergilus fumigatus up to the maximum tested concentration of 1,000 µg/mL.
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spelling pubmed-62706232018-12-17 Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors Paszkowska, Jadwiga Kral, Katarzyna Bieg, Tadeusz Nawrot, Urszula Szeja, Wiesław Wandzik, Ilona Molecules Article New derivatives of uridine which contain a β-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1–4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were not active against Candida albicans and Aspergilus fumigatus up to the maximum tested concentration of 1,000 µg/mL. MDPI 2013-07-08 /pmc/articles/PMC6270623/ /pubmed/23884133 http://dx.doi.org/10.3390/molecules18078018 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Paszkowska, Jadwiga
Kral, Katarzyna
Bieg, Tadeusz
Nawrot, Urszula
Szeja, Wiesław
Wandzik, Ilona
Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors
title Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors
title_full Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors
title_fullStr Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors
title_full_unstemmed Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors
title_short Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors
title_sort synthesis and preliminary biological evaluations of 5′-substituted derivatives of uridine as glycosyltransferase inhibitors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270623/
https://www.ncbi.nlm.nih.gov/pubmed/23884133
http://dx.doi.org/10.3390/molecules18078018
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