Phenolic Esters of O-Desmethylvenlafaxine with Improved Oral Bioavailability and Brain Uptake

O-Desmethylvenlafaxine (desvenlafaxine, ODV) is a recently approved antidepressant which in some clinical studies failed to meet a satisfactory end-point. The aim of this study was to prepare a series of phenolic esters of ODV and evaluate their potential as ODV prodrugs with improved brain uptake....

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Detalles Bibliográficos
Autores principales: Zhang, Yang, Yang, Yan, Zhao, Sen, Yang, Zhichao, Yang, Hong, Fawcett, J. Paul, Li, Youxin, Gu, Jingkai, Sun, Tiemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270635/
https://www.ncbi.nlm.nih.gov/pubmed/24304586
http://dx.doi.org/10.3390/molecules181214920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270635/
https://www.ncbi.nlm.nih.gov/pubmed/24304586
http://dx.doi.org/10.3390/molecules181214920

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