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Phenolic Esters of O-Desmethylvenlafaxine with Improved Oral Bioavailability and Brain Uptake

O-Desmethylvenlafaxine (desvenlafaxine, ODV) is a recently approved antidepressant which in some clinical studies failed to meet a satisfactory end-point. The aim of this study was to prepare a series of phenolic esters of ODV and evaluate their potential as ODV prodrugs with improved brain uptake....

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Detalles Bibliográficos
Autores principales:	Zhang, Yang, Yang, Yan, Zhao, Sen, Yang, Zhichao, Yang, Hong, Fawcett, J. Paul, Li, Youxin, Gu, Jingkai, Sun, Tiemin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270635/ https://www.ncbi.nlm.nih.gov/pubmed/24304586 http://dx.doi.org/10.3390/molecules181214920

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