Antileishmanial Lead Structures from Nature: Analysis of Structure-Activity Relationships of a Compound Library Derived from Caffeic Acid Bornyl Ester

Bioassay-guided fractionation of a chloroform extract of Valeriana wallichii (V. wallichii) rhizomes lead to the isolation and identification of caffeic acid bornyl ester (1) as the active component against Leishmania major (L. major) promastigotes (IC(50) = 48.8 µM). To investigate the structure-ac...

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Detalles Bibliográficos
Autores principales: Glaser, Jan, Schultheis, Martina, Hazra, Sudipta, Hazra, Banasri, Moll, Heidrun, Schurigt, Uta, Holzgrabe, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270661/
https://www.ncbi.nlm.nih.gov/pubmed/24473204
http://dx.doi.org/10.3390/molecules19021394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270661/
https://www.ncbi.nlm.nih.gov/pubmed/24473204
http://dx.doi.org/10.3390/molecules19021394

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