T-Type Ca(2+) Channel Blocker, KYS05090 Induces Autophagy and Apoptosis in A549 Cells through Inhibiting Glucose Uptake

It has been reported that [3-(1,1'-biphenyl-4-yl)-2-(1-methyl-5-dimethylamino-pentylamino)-3,4-dihydroquinazolin-4-yl]-N-benzylacetamide 2hydrochloride (KYS05090), a selective T-type Ca(2+) channel blocker, reduces tumor volume and weight in the A549 xenograft model, but the molecular mechanism...

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Detalles Bibliográficos
Autores principales: Rim, Hong-Kun, Cho, Sehyeon, Shin, Dong-Hyun, Chung, Kyung-Sook, Cho, Young-Wuk, Choi, Jung-Hye, Lee, Jae Yeol, Lee, Kyung-Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270691/
https://www.ncbi.nlm.nih.gov/pubmed/25006791
http://dx.doi.org/10.3390/molecules19079864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270691/
https://www.ncbi.nlm.nih.gov/pubmed/25006791
http://dx.doi.org/10.3390/molecules19079864

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