Ionization States, Cellular Toxicity and Molecular Modeling Studies of Midazolam Complexed with Trimethyl-β-Cyclodextrin

We investigated the ionization profiles for open-ring (OR) and closed-ring (CR) forms of midazolam and drug-binding modes with heptakis-(2,3,6-tri-O-methyl)-β-cyclodextrin (trimethyl-β-cyclodextrin; TRIMEB) using molecular modeling techniques and quantum mechanics methods. The results indicated that...

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Detalles Bibliográficos
Autores principales: Shityakov, Sergey, Sohajda, Tamás, Puskás, István, Roewer, Norbert, Förster, Carola, Broscheit, Jens-Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270744/
https://www.ncbi.nlm.nih.gov/pubmed/25338177
http://dx.doi.org/10.3390/molecules191016861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270744/
https://www.ncbi.nlm.nih.gov/pubmed/25338177
http://dx.doi.org/10.3390/molecules191016861

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