K(2)CO(3)-Mediated Synthesis of Functionalised 4-Substituted-2-amino-3-cyano-4H-chromenes via Michael-Cyclization Reactions

An efficient approach for the synthesis of functionalized 4-substituted-2-amino-3-cyano-4H-chromenes moderate to high yields (up to 98%) has been achieved via a tandem K(2)CO(3 )catalyzed conjugate addition-cyclization reaction of malononitrile and a range of Knoevenagel adducts previously formed fr...

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Autores principales: He, Yanyang, Hu, Rong, Tong, Rongsheng, Li, Fengqiong, Shi, Jianyou, Zhang, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270755/
https://www.ncbi.nlm.nih.gov/pubmed/25429557
http://dx.doi.org/10.3390/molecules191219253
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author He, Yanyang
Hu, Rong
Tong, Rongsheng
Li, Fengqiong
Shi, Jianyou
Zhang, Mei
author_facet He, Yanyang
Hu, Rong
Tong, Rongsheng
Li, Fengqiong
Shi, Jianyou
Zhang, Mei
author_sort He, Yanyang
collection PubMed
description An efficient approach for the synthesis of functionalized 4-substituted-2-amino-3-cyano-4H-chromenes moderate to high yields (up to 98%) has been achieved via a tandem K(2)CO(3 )catalyzed conjugate addition-cyclization reaction of malononitrile and a range of Knoevenagel adducts previously formed from oxindole, pyrazolone, nitromethane, N,N-dimethylbarbituric acid or indanedione. This methodology differs from the previous classical methods in its simplicity and ready availability of the catalyst.
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spelling pubmed-62707552018-12-28 K(2)CO(3)-Mediated Synthesis of Functionalised 4-Substituted-2-amino-3-cyano-4H-chromenes via Michael-Cyclization Reactions He, Yanyang Hu, Rong Tong, Rongsheng Li, Fengqiong Shi, Jianyou Zhang, Mei Molecules Article An efficient approach for the synthesis of functionalized 4-substituted-2-amino-3-cyano-4H-chromenes moderate to high yields (up to 98%) has been achieved via a tandem K(2)CO(3 )catalyzed conjugate addition-cyclization reaction of malononitrile and a range of Knoevenagel adducts previously formed from oxindole, pyrazolone, nitromethane, N,N-dimethylbarbituric acid or indanedione. This methodology differs from the previous classical methods in its simplicity and ready availability of the catalyst. MDPI 2014-11-25 /pmc/articles/PMC6270755/ /pubmed/25429557 http://dx.doi.org/10.3390/molecules191219253 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
He, Yanyang
Hu, Rong
Tong, Rongsheng
Li, Fengqiong
Shi, Jianyou
Zhang, Mei
K(2)CO(3)-Mediated Synthesis of Functionalised 4-Substituted-2-amino-3-cyano-4H-chromenes via Michael-Cyclization Reactions
title K(2)CO(3)-Mediated Synthesis of Functionalised 4-Substituted-2-amino-3-cyano-4H-chromenes via Michael-Cyclization Reactions
title_full K(2)CO(3)-Mediated Synthesis of Functionalised 4-Substituted-2-amino-3-cyano-4H-chromenes via Michael-Cyclization Reactions
title_fullStr K(2)CO(3)-Mediated Synthesis of Functionalised 4-Substituted-2-amino-3-cyano-4H-chromenes via Michael-Cyclization Reactions
title_full_unstemmed K(2)CO(3)-Mediated Synthesis of Functionalised 4-Substituted-2-amino-3-cyano-4H-chromenes via Michael-Cyclization Reactions
title_short K(2)CO(3)-Mediated Synthesis of Functionalised 4-Substituted-2-amino-3-cyano-4H-chromenes via Michael-Cyclization Reactions
title_sort k(2)co(3)-mediated synthesis of functionalised 4-substituted-2-amino-3-cyano-4h-chromenes via michael-cyclization reactions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270755/
https://www.ncbi.nlm.nih.gov/pubmed/25429557
http://dx.doi.org/10.3390/molecules191219253
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