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Investigation of the Flexibility of Protein Kinases Implicated in the Pathology of Alzheimer’s Disease

The pathological characteristics of Alzheimer’s Disease (AD) have been linked to the activity of three particular kinases—Glycogen Synthase Kinase 3β (GSK3β), Cyclin-Dependent Kinase 5 (CDK5) and Extracellular-signal Regulated Kinase 2 (ERK2). As a consequence, the design of selective, potent and dr...

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Detalles Bibliográficos
Autores principales: Mazanetz, Michael P., Laughton, Charles A., Fischer, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270768/
https://www.ncbi.nlm.nih.gov/pubmed/24983862
http://dx.doi.org/10.3390/molecules19079134