Validation of a Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry Method for Determination of All-Trans Retinoic Acid in Human Plasma and Its Application to a Bioequivalence Study

A sensitive, reliable and specific LC-MS-MS method was developed and validated for the identification and quantitation of all-trans retinoic acid (ATRA) in human plasma. Acitretin was used as the internal standard (IS). After liquid-liquid extraction of 500 μL plasma with methyl tert-butyl ether (MT...

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Detalles Bibliográficos
Autores principales: Peng, Jing-Bo, Luo, Chen-Hui, Wang, Yi-Cheng, Huang, Wei-Hua, Chen, Yao, Zhou, Hong-Hao, Tan, Zhi-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270799/
https://www.ncbi.nlm.nih.gov/pubmed/24445345
http://dx.doi.org/10.3390/molecules19011189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270799/
https://www.ncbi.nlm.nih.gov/pubmed/24445345
http://dx.doi.org/10.3390/molecules19011189

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