Synthesis and Biological Evaluation of Novel 10-Substituted-7-ethyl-10-hydroxycamptothecin (SN-38) Prodrugs

In an attempt to improve the antitumor activity and reduce the side effects of irinotecan (2), novel prodrugs of SN-38 (3) were prepared by conjugating amino acids or dipeptides to the 10-hydroxyl group of SN-38 via a carbamate linkage. The synthesized compounds completely generated SN-38 in pH 7.4...

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Detalles Bibliográficos
Autores principales: Zhou, Mo, Liu, Meixia, He, Xinhua, Yu, Hong, Wu, Di, Yao, Yishan, Fan, Shiyong, Zhang, Ping, Shi, Weiguo, Zhong, Bohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270839/
https://www.ncbi.nlm.nih.gov/pubmed/25438082
http://dx.doi.org/10.3390/molecules191219718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270839/
https://www.ncbi.nlm.nih.gov/pubmed/25438082
http://dx.doi.org/10.3390/molecules191219718

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