Intracellular Glutathione Depletion by Oridonin Leads to Apoptosis in Hepatic Stellate Cells

Proliferation of hepatic stellate cells (HSCs) plays a key role in the pathogenesis of liver fibrosis. Induction of HSC apoptosis by natural products is considered an effective strategy for treating liver fibrosis. Herein, the apoptotic effects of 7,20-epoxy-ent-kaurane (oridonin), a diterpenoid iso...

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Detalles Bibliográficos
Autores principales: Kuo, Liang-Mou, Kuo, Chan-Yen, Lin, Chen-Yu, Hung, Min-Fa, Shen, Jiann-Jong, Hwang, Tsong-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270846/
https://www.ncbi.nlm.nih.gov/pubmed/24647034
http://dx.doi.org/10.3390/molecules19033327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270846/
https://www.ncbi.nlm.nih.gov/pubmed/24647034
http://dx.doi.org/10.3390/molecules19033327

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