Cargando…

Identification of Two Novel α(1)-AR Agonists Using a High-Throughput Screening Model

α(1)-Adrenoceptors (ARs; 1A, 1B, and 1D) have been determined to perform different prominent functions in the physiological responses of the sympathetic nervous system. A high-throughput screening assay (HTS) was set up to detect α(1)-AR subtype-selective agonists by a dual-luciferase reporter assay...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Fang, Chen, Hong, He, Xuelan, Xu, Jingyi, Xu, Bingbing, Huang, Biyun, Liang, Xue, Yuan, Mu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270864/ https://www.ncbi.nlm.nih.gov/pubmed/25140448 http://dx.doi.org/10.3390/molecules190812699

Ejemplares similares

Synthesis and Cytotoxic Activity Evaluation of Novel Arylpiperazine Derivatives on Human Prostate Cancer Cell Lines
por: Chen, Hong, et al.
Publicado: (2014)

Identification and characterization of an atypical Gαs-biased β(2)AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis
por: Kim, Donghwa, et al.
Publicado: (2021)

A Novel Role for RARα Agonists as Apolipoprotein CIII Inhibitors Identified from High Throughput Screening
por: Lee, Sang Jun, et al.
Publicado: (2017)

Combined Therapy of A(1)AR Agonists and A(2A)AR Antagonists in Neuroinflammation
por: Marucci, Gabriella, et al.
Publicado: (2021)

Function-based high-throughput screening for antibody antagonists and agonists against G protein-coupled receptors
por: Ren, Huanhuan, et al.
Publicado: (2020)

Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone
por: Wang, Xue-Jiao, et al.
Publicado: (2014)

Cheminformatics analysis of the AR agonist and antagonist datasets in PubChem
por: Hao, Ming, et al.
Publicado: (2016)

Identification of a nanomolar affinity α-synuclein fibril imaging probe by ultra-high throughput in silico screening
por: Ferrie, John J., et al.
Publicado: (2020)

Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells
por: Leister, Kristin P, et al.
Publicado: (2011)

The “C3aR Antagonist” SB290157 is a Partial C5aR2 Agonist
por: Li, Xaria X., et al.
Publicado: (2021)

High-throughput screening for agonists of ROS production in live human vascular endothelial cells
por: Sasahara, Tomoya, et al.
Publicado: (2021)

Identification of multiple salicylic acid-binding proteins using two high throughput screens
por: Manohar, Murli, et al.
Publicado: (2015)

Model structures of inactive and peptide agonist bound C5aR: Insights into agonist binding, selectivity and activation
por: Rana, Soumendra, et al.
Publicado: (2015)

High-throughput AR dimerization assay identifies androgen disrupting chemicals and metabolites
por: Brown, Evan C., et al.
Publicado: (2023)

Baicalein suppresses the androgen receptor (AR)-mediated prostate cancer progression via inhibiting the AR N-C dimerization and AR-coactivators interaction
por: Xu, Defeng, et al.
Publicado: (2017)

Comparative Transcriptome Profiling of Cold Exposure and β3-AR Agonist CL316,243-Induced Browning of White Fat
por: Li, Yu, et al.
Publicado: (2021)

Identification of an AR Mutation-Negative Class of Androgen Insensitivity by Determining Endogenous AR Activity
por: Hornig, N. C., et al.
Publicado: (2016)

Identification of AR-V7 downstream genes commonly targeted by AR/AR-V7 and specifically targeted by AR-V7 in castration resistant prostate cancer
por: Sugiura, Masahiro, et al.
Publicado: (2020)

Allosteric modulator potentiates β(2)AR agonist–promoted bronchoprotection in asthma models
por: Ahn, Seungkirl, et al.
Publicado: (2023)

Identification of new drug candidates against Trichomonas gallinae using high-throughput screening
por: Jing, Shengfan, et al.
Publicado: (2023)

Identification of Adiponectin Receptor Agonist Utilizing a Fluorescence Polarization Based High Throughput Assay
por: Sun, Yiyi, et al.
Publicado: (2013)

High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses
por: Shen, Liang, et al.
Publicado: (2019)

High-throughput de novo screening of receptor agonists with an automated single-cell analysis and isolation system
por: Yoshimoto, Nobuo, et al.
Publicado: (2014)

High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist
por: Lin, Guangyao, et al.
Publicado: (2021)

Cell-based high-throughput screening of polysaccharide biosynthesis hosts
por: Liu, Zi-Xu, et al.
Publicado: (2021)

Development of a Rapid Throughput Assay for Identification of hNa(v)1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin
por: Zhao, Fang, et al.
Publicado: (2016)

TMEM158 expression is negatively regulated by AR signaling and associated with favorite survival outcomes in prostate cancers
por: Huang, Jian, et al.
Publicado: (2022)

High-Throughput Screening to Identify Inhibitors of Plasmodium falciparum Importin α
por: Walunj, Sujata B., et al.
Publicado: (2022)

$^{43}$Ar and $^{44}$Ar
por: Hudis, J, et al.
Publicado: (1970)

$^{43}Ar$ and $^{44}Ar$
por: Hudis, J, et al.
Publicado: (1970)

To Be(Ar) Or Not to Be(Ar) – Jones Dilemma?
por: Andrews, Nicholas A., et al.
Publicado: (2022)

Structural insights into binding specificity, efficacy and bias of a β(2)AR partial agonist
por: Masureel, Matthieu, et al.
Publicado: (2018)

β-blockers Reverse Agonist-Induced β(2)-AR Downregulation Regardless of Their Signaling Profile
por: Maccari, Sonia, et al.
Publicado: (2020)

Identification of Compounds That Interfere with High‐Throughput Screening Assay Technologies
por: David, Laurianne, et al.
Publicado: (2019)

High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4
por: Lin, Guang-yao, et al.
Publicado: (2020)

Polydiacetylene-Based High-Throughput Screen for Surfactin Producing Strains of Bacillus subtilis
por: Zhu, Lingyan, et al.
Publicado: (2014)

Two-proton emission in the decay of $^{31}$Ar
por: Axelsson, L, et al.
Publicado: (1998)

Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens
por: Schorpp, Kenji, et al.
Publicado: (2014)

Screening Tumor-Related Genes of Gallbladder Cancer Based on AR-Based Tumor Expression Profile Gene Chip
por: Guo, Jia, et al.
Publicado: (2022)

PPAR-α Agonist Fenofibrate Decreased RANTES Levels in Type 2 Diabetes Patients with Hypertriglyceridemia
por: Feng, Xiaomeng, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_2j6ntog7kfck8kpatjem0jcls8