Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines

Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6–12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB23...

Descripción completa

Detalles Bibliográficos
Autores principales: Montenegro, Ivan, Tomasoni, Giacomo, Bosio, Claudia, Quiñones, Natalia, Madrid, Alejandro, Carrasco, Hector, Olea, Andres, Martinez, Rolando, Cuellar, Mauricio, Villena, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270921/
https://www.ncbi.nlm.nih.gov/pubmed/25412045
http://dx.doi.org/10.3390/molecules191118993
_version_ 1783376809877831680
author Montenegro, Ivan
Tomasoni, Giacomo
Bosio, Claudia
Quiñones, Natalia
Madrid, Alejandro
Carrasco, Hector
Olea, Andres
Martinez, Rolando
Cuellar, Mauricio
Villena, Joan
author_facet Montenegro, Ivan
Tomasoni, Giacomo
Bosio, Claudia
Quiñones, Natalia
Madrid, Alejandro
Carrasco, Hector
Olea, Andres
Martinez, Rolando
Cuellar, Mauricio
Villena, Joan
author_sort Montenegro, Ivan
collection PubMed
description Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6–12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC(50) values were determined at concentrations of 12.5–100 µM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells.
format Online
Article
Text
id pubmed-6270921
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62709212019-01-07 Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines Montenegro, Ivan Tomasoni, Giacomo Bosio, Claudia Quiñones, Natalia Madrid, Alejandro Carrasco, Hector Olea, Andres Martinez, Rolando Cuellar, Mauricio Villena, Joan Molecules Article Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6–12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC(50) values were determined at concentrations of 12.5–100 µM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells. MDPI 2014-11-18 /pmc/articles/PMC6270921/ /pubmed/25412045 http://dx.doi.org/10.3390/molecules191118993 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Montenegro, Ivan
Tomasoni, Giacomo
Bosio, Claudia
Quiñones, Natalia
Madrid, Alejandro
Carrasco, Hector
Olea, Andres
Martinez, Rolando
Cuellar, Mauricio
Villena, Joan
Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines
title Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines
title_full Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines
title_fullStr Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines
title_full_unstemmed Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines
title_short Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines
title_sort study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270921/
https://www.ncbi.nlm.nih.gov/pubmed/25412045
http://dx.doi.org/10.3390/molecules191118993
work_keys_str_mv AT montenegroivan studyonthecytotoxicactivityofdrimanesesquiterpenesandnordrimanecompoundsagainstcancercelllines
AT tomasonigiacomo studyonthecytotoxicactivityofdrimanesesquiterpenesandnordrimanecompoundsagainstcancercelllines
AT bosioclaudia studyonthecytotoxicactivityofdrimanesesquiterpenesandnordrimanecompoundsagainstcancercelllines
AT quinonesnatalia studyonthecytotoxicactivityofdrimanesesquiterpenesandnordrimanecompoundsagainstcancercelllines
AT madridalejandro studyonthecytotoxicactivityofdrimanesesquiterpenesandnordrimanecompoundsagainstcancercelllines
AT carrascohector studyonthecytotoxicactivityofdrimanesesquiterpenesandnordrimanecompoundsagainstcancercelllines
AT oleaandres studyonthecytotoxicactivityofdrimanesesquiterpenesandnordrimanecompoundsagainstcancercelllines
AT martinezrolando studyonthecytotoxicactivityofdrimanesesquiterpenesandnordrimanecompoundsagainstcancercelllines
AT cuellarmauricio studyonthecytotoxicactivityofdrimanesesquiterpenesandnordrimanecompoundsagainstcancercelllines
AT villenajoan studyonthecytotoxicactivityofdrimanesesquiterpenesandnordrimanecompoundsagainstcancercelllines

Ejemplares similares