Synthesis and Relaxivity Studies of a DOTA-Based Nanomolecular Chelator Assembly Supported by an Icosahedral Closo-B(12)(2−) -Core for MRI: A Click Chemistry Approach

An icosahedral closo-B(12)(2−) scaffold based nano-sized assembly capable of carrying a high payload of Gd(3+)-chelates in a sterically crowded configuration is developed by employing the azide-alkyne click reaction. The twelve copies of DO3A-t-Bu-ester ligands were covalently attached to an icosahe...

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Detalles Bibliográficos
Autores principales: Goswami, Lalit N., Ma, Lixin, Kueffer, Peter J., Jalisatgi, Satish S., Hawthorne, M. Frederick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270972/
https://www.ncbi.nlm.nih.gov/pubmed/23899836
http://dx.doi.org/10.3390/molecules18089034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270972/
https://www.ncbi.nlm.nih.gov/pubmed/23899836
http://dx.doi.org/10.3390/molecules18089034

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