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Synthesis and Relaxivity Studies of a DOTA-Based Nanomolecular Chelator Assembly Supported by an Icosahedral Closo-B(12)(2−) -Core for MRI: A Click Chemistry Approach
An icosahedral closo-B(12)(2−) scaffold based nano-sized assembly capable of carrying a high payload of Gd(3+)-chelates in a sterically crowded configuration is developed by employing the azide-alkyne click reaction. The twelve copies of DO3A-t-Bu-ester ligands were covalently attached to an icosahe...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270972/ https://www.ncbi.nlm.nih.gov/pubmed/23899836 http://dx.doi.org/10.3390/molecules18089034 |