Synthesis and Biological Evaluation of Novel 2-Arylalkylthio-5-iodine-6-substituted-benzyl-pyrimidine-4(3H)-ones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

A novel series of 2-arylalkylthio-5-iodine-6-substitutedbenzyl-pyrimidine-4(3H)-ones (S-DABOs) 8a–x had been synthesized via an efficient method. Their biological activity against HIV virus and RT assay were evaluated. Some compounds, especially 8h, 8l and 8n, displayed promising activity against HI...

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Detalles Bibliográficos
Autores principales: Zhang, Liang, Tang, Xiaowan, Cao, Yuanyuan, Wu, Shaotong, Zhang, Yu, Zhao, Jianxiong, Guo, Ying, Tian, Chao, Zhang, Zhili, Liu, Junyi, Wang, Xiaowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271041/
https://www.ncbi.nlm.nih.gov/pubmed/24886938
http://dx.doi.org/10.3390/molecules19067104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271041/
https://www.ncbi.nlm.nih.gov/pubmed/24886938
http://dx.doi.org/10.3390/molecules19067104

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