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Selective Substitution of 31/42–OH in Rapamycin Guided by an in Situ IR Technique
An in situ IR technique was applied in the selective synthesis of the key intermediate for rapamycin derivatives, which made the reaction endpoint easily defined. This technology solved a bothersome problem in the preparation of rapamycin derivatives, and based on this technique, the 31-OH and 42-OH...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271078/ https://www.ncbi.nlm.nih.gov/pubmed/24918544 http://dx.doi.org/10.3390/molecules19067770 |