1,2-Substituted 4-(1H)-Quinolones: Synthesis, Antimalarial and Antitrypanosomal Activities in Vitro

A diverse array of 4-(1H)-quinolone derivatives bearing substituents at positions 1 and 2 were synthesized and evaluated for antiprotozoal activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense, and cytotoxicity against L-6 cells in vitro. Furthermore, selectivity indices were a...

Descripción completa

Detalles Bibliográficos
Autores principales: Wube, Abraham, Hüfner, Antje, Seebacher, Werner, Kaiser, Marcel, Brun, Reto, Bauer, Rudolf, Bucar, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271202/
https://www.ncbi.nlm.nih.gov/pubmed/25211002
http://dx.doi.org/10.3390/molecules190914204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271202/
https://www.ncbi.nlm.nih.gov/pubmed/25211002
http://dx.doi.org/10.3390/molecules190914204

Ejemplares similares