Synthesis, Molecular Docking and Biological Evaluation of Glycyrrhizin Analogs as Anticancer Agents Targeting EGFR

Glycyrrhizin (GA) analogs in the form of 3-glucuronides and 18-epimers were synthesized and their anticancer activities were evaluated. Alkaline isomerization of monoglucuronides is reported. In vitro and in vivo studies showed that glycyrrhetinic acid monoglucuronides (GAMGs) displayed higher antic...

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Detalles Bibliográficos
Autores principales: Yang, Yong-An, Tang, Wen-Jian, Zhang, Xin, Yuan, Ji-Wen, Liu, Xin-Hua, Zhu, Hai-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271220/
https://www.ncbi.nlm.nih.gov/pubmed/24853453
http://dx.doi.org/10.3390/molecules19056368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271220/
https://www.ncbi.nlm.nih.gov/pubmed/24853453
http://dx.doi.org/10.3390/molecules19056368

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