Cargando…

Synthesis, Molecular Docking and Biological Evaluation of Glycyrrhizin Analogs as Anticancer Agents Targeting EGFR

Glycyrrhizin (GA) analogs in the form of 3-glucuronides and 18-epimers were synthesized and their anticancer activities were evaluated. Alkaline isomerization of monoglucuronides is reported. In vitro and in vivo studies showed that glycyrrhetinic acid monoglucuronides (GAMGs) displayed higher antic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Yong-An, Tang, Wen-Jian, Zhang, Xin, Yuan, Ji-Wen, Liu, Xin-Hua, Zhu, Hai-Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271220/ https://www.ncbi.nlm.nih.gov/pubmed/24853453 http://dx.doi.org/10.3390/molecules19056368

Ejemplares similares

Synthesis, Biological Evaluation, and Molecular Docking of Novel Azolylhydrazonothiazoles as Potential Anticancer Agents
por: Al-Humaidi, Jehan Y., et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Analogs of Didehydroepiandrosterone as Potential New Anticancer Agents
por: J. Solum, Eirik, et al.
Publicado: (2020)

Novel quinoxaline derivatives as dual EGFR and COX-2 inhibitors: synthesis, molecular docking and biological evaluation as potential anticancer and anti-inflammatory agents
por: Ahmed, Eman A., et al.
Publicado: (2022)

Novel Pyrimidine Derivatives as Potential Anticancer Agents: Synthesis, Biological Evaluation and Molecular Docking Study
por: Tylińska, Beata, et al.
Publicado: (2021)

Design, synthesis, molecular docking and biological evaluation of new carbazole derivatives as anticancer, and antioxidant agents
por: Çapan, İrfan, et al.
Publicado: (2023)

Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study
por: El-Sayed, Magda A.-A., et al.
Publicado: (2017)

Novel saccharin analogs as promising antibacterial and anticancer agents: synthesis, DFT, POM analysis, molecular docking, molecular dynamic simulations, and cell-based assay
por: Abdellattif, Magda H., et al.
Publicado: (2022)

Design, synthesis, and biological evaluation of novel bioactive thalidomide analogs as anticancer immunomodulatory agents
por: Kotb, Anas Ramadan, et al.
Publicado: (2022)

A novel medium size lactam ring analoges as antibacterial agents: Synthesis, biological evaluation and molecular docking studies
por: Harita, Putcha A. N. V., et al.
Publicado: (2017)

Synthesis, biological evaluation and molecular docking of new triphenylamine-linked pyridine, thiazole and pyrazole analogues as anticancer agents
por: Elmorsy, Mohamed R., et al.
Publicado: (2022)

Synthesis, Biological Activity, ADME and Molecular Docking Studies of Novel Ursolic Acid Derivatives as Potent Anticancer Agents
por: Michalak, Olga, et al.
Publicado: (2023)

Design and Synthesis of Carbothioamide/Carboxamide-Based Pyrazoline Analogs as Potential Anticancer Agents: Apoptosis, Molecular Docking, ADME Assay, and DNA Binding Studies
por: Rana, Manish, et al.
Publicado: (2022)

Synthesis, Docking and Biological Activities of Novel Hybrids Celecoxib and Anthraquinone Analogs as Potent Cytotoxic Agents
por: Almutairi, Maha S., et al.
Publicado: (2014)

Novel Sulfonamide–Triazine Hybrid Derivatives: Docking, Synthesis, and Biological Evaluation as Anticancer Agents
por: Alelaimat, Mahmoud A., et al.
Publicado: (2023)

Design, Synthesis, Cytotoxic Evaluation and Molecular Docking of New Fluoroquinazolinones as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects
por: Zayed, Mohamed F., et al.
Publicado: (2018)

Correction to “Design and Synthesis of Carbothioamide/Carboxamide-Based Pyrazoline Analogs as Potential Anticancer Agents: Apoptosis, Molecular Docking, ADME Assay, and DNA Binding Studies”
por: Rana, Manish, et al.
Publicado: (2022)

Mechanochemical Synthesis and Molecular Docking Studies of New Azines Bearing Indole as Anticancer Agents
por: Ibrahim, Mohamed S., et al.
Publicado: (2023)

Molecular Docking Compounds of Cinnamaldehyde Derivatives as Anticancer Agents
por: Warsito, Warsito, et al.
Publicado: (2021)

Design, Synthesis, Molecular Docking, and Biological Evaluation of Pyrazole Hybrid Chalcone Conjugates as Potential Anticancer Agents and Tubulin Polymerization Inhibitors
por: Alam, Md. Jahangir, et al.
Publicado: (2022)

Design, Synthesis, Molecular Docking Study and Biological Evaluation of Novel γ-Carboline Derivatives of Latrepirdine (Dimebon) as Potent Anticancer Agents
por: Voggu, Ramakrishna, et al.
Publicado: (2023)

Synthesis, Biological Evaluation and Molecular Docking of Novel Indole-Aminoquinazoline Hybrids for Anticancer Properties
por: Mphahlele, Malose J., et al.
Publicado: (2018)

Design, Synthesis, and Molecular Docking Studies of Some New Quinoxaline Derivatives as EGFR Targeting Agents
por: Badithapuram, Vinitha, et al.
Publicado: (2022)

Synthesis and Evaluation of L-Glutamic acid Analogs as Potential Anticancer Agents
por: Vishwanathan, C. L., et al.
Publicado: (2008)

Design, efficient synthesis and molecular docking of some novel thiazolyl-pyrazole derivatives as anticancer agents
por: Sayed, Abdelwahed R., et al.
Publicado: (2019)

Novel N-Acyl Hydrazone Compounds as Promising Anticancer Agents: Synthesis and Molecular Docking Studies
por: Biliz, Yağmur, et al.
Publicado: (2023)

Synthesis, Antimicrobial, Anticancer, PASS, Molecular Docking, Molecular Dynamic Simulations & Pharmacokinetic Predictions of Some Methyl β-D-Galactopyranoside Analogs
por: Amin, Md. Ruhul, et al.
Publicado: (2021)

Design, synthesis and biological evaluation of N-arylsulfonyl carbazoles as novel anticancer agents
por: You, Xin, et al.
Publicado: (2018)

N-phenyl-6-chloro-4-hydroxy-2-quinolone-3-carboxamides: Molecular Docking, Synthesis, and Biological Investigation as Anticancer Agents
por: Sabbah, Dima A., et al.
Publicado: (2020)

Promising Antibacterial and Antifungal Agents Based on Thiolated Vitamin K3 Analogs: Synthesis, Bioevaluation, Molecular Docking
por: Yıldırım, Hatice, et al.
Publicado: (2022)

2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights
por: Elbadawi, Mostafa M., et al.
Publicado: (2021)

Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation
por: Ashraf, Zaman, et al.
Publicado: (2019)

Amino Acid Conjugates of Aminothiazole and Aminopyridine as Potential Anticancer Agents: Synthesis, Molecular Docking and in vitro Evaluation
por: Naz, Shagufta, et al.
Publicado: (2021)

Novel 4-Azapregnene Derivatives as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies
por: Brito, Vanessa, et al.
Publicado: (2022)

Biological Activities and Molecular Docking of Brassinosteroids 24-Norcholane Type Analogs
por: Díaz, Katy, et al.
Publicado: (2020)

Photoinduced Synthesis of Methylated Marine Cyclopeptide Galaxamide Analogs with Isoindolinone as Anticancer Agents
por: Xiao, Shimei, et al.
Publicado: (2022)

The application of click chemistry in the synthesis of agents with anticancer activity
por: Ma, Nan, et al.
Publicado: (2015)

Synthesis and discovery of 18α-GAMG as anticancer agent in vitro and in vivo via down expression of protein p65
por: Tang, Wen-jian, et al.
Publicado: (2014)

Design, synthesis, biological evaluation and molecular docking study of novel pleuromutilin derivatives containing substituted benzoxazole as antibacterial agents
por: Ren, Jie, et al.
Publicado: (2023)

Docking Studies and Biological Activity of Fosinopril Analogs
por: Choudary, Jayant, et al.
Publicado: (2014)

Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents
por: Krzywik, Julia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_uhraobip33vb3bpkuk2i7btl4t