DNA Condensation by Partially Acetylated Poly(amido amine) Dendrimers: Effects of Dendrimer Charge Density on Complex Formation

The ability of poly(amido amine) (or PAMAM) dendrimers to condense semiflexible dsDNA and penetrate cell membranes gives them great potential in gene therapy and drug delivery but their high positive surface charge makes them cytotoxic. Here, we describe the effects of partial neutralization by acet...

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Detalles Bibliográficos
Autores principales: Yu, Shi, Li, Ming-Hsin, Choi, Seok Ki, Baker, James R., Larson, Ronald G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271276/
https://www.ncbi.nlm.nih.gov/pubmed/24005965
http://dx.doi.org/10.3390/molecules180910707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271276/
https://www.ncbi.nlm.nih.gov/pubmed/24005965
http://dx.doi.org/10.3390/molecules180910707

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