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Pharmacophore Generation from a Drug-like Core Molecule Surrounded by a Library Peptide via the 10BASE(d)-T on Bacteriophage T7

We have achieved site-specific conjugation of several haloacetamide derivatives into designated cysteines on bacteriophage T7-displayed peptides, which are fused to T7 capsid protein gp10. This easiest gp10 based-thioetherification (10BASE(d)-T) undergoes almost quantitatively like a click reaction...

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Detalles Bibliográficos
Autores principales:	Tokunaga, Yuuki, Azetsu, Yuuki, Fukunaga, Keisuke, Hatanaka, Takaaki, Ito, Yuji, Taki, Masumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271298/ https://www.ncbi.nlm.nih.gov/pubmed/24566316 http://dx.doi.org/10.3390/molecules19022481

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