Synthesis and Docking Studies of 2,4,6-Trihydroxy-3-Geranylacetophenone Analogs as Potential Lipoxygenase Inhibitor

The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of...

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Detalles Bibliográficos
Autores principales: Ng, Chean Hui, Rullah, Kamal, Aluwi, Mohd Fadhlizil Fasihi Mohd, Abas, Faridah, Lam, Kok Wai, Ismail, Intan Safinar, Narayanaswamy, Radhakrishnan, Jamaludin, Fadzureena, Shaari, Khozirah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271415/
https://www.ncbi.nlm.nih.gov/pubmed/25100256
http://dx.doi.org/10.3390/molecules190811645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271415/
https://www.ncbi.nlm.nih.gov/pubmed/25100256
http://dx.doi.org/10.3390/molecules190811645

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