Effects of Single Amino Acid Substitution on the Biophysical Properties and Biological Activities of an Amphipathic α-Helical Antibacterial Peptide Against Gram-Negative Bacteria

An antimicrobial peptide, known as V13K, was utilized as the framework to study the effects of charge, hydrophobicity and helicity on the biophysical properties and biological activities of α-helical peptides. Six amino acids (Lys, Glu, Gly, Ser, Ala, and Leu) were individually used to substitute th...

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Detalles Bibliográficos
Autores principales: Tan, Juanjuan, Huang, Jinfeng, Huang, Yibing, Chen, Yuxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271477/
https://www.ncbi.nlm.nih.gov/pubmed/25061725
http://dx.doi.org/10.3390/molecules190810803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271477/
https://www.ncbi.nlm.nih.gov/pubmed/25061725
http://dx.doi.org/10.3390/molecules190810803

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