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TOMBU and COMBU as Novel Uronium-Type Peptide Coupling Reagents Derived from Oxyma-B
Here we describe two novel uronium salts, TOMBU and COMBU, derived from the recently described Oxyma-B for use in peptide bond synthesis. These coupling reagents are more stable than COMU in DMF. Furthermore, using various peptide synthetic models in solution and solid-phase synthesis, we reveal tha...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271478/ https://www.ncbi.nlm.nih.gov/pubmed/25412042 http://dx.doi.org/10.3390/molecules191118953 |
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author | Jad, Yahya E. Khattab, Sherine N. de la Torre, Beatriz G. Govender, Thavendran Kruger, Hendrik G. El-Faham, Ayman Albericio, Fernando |
author_facet | Jad, Yahya E. Khattab, Sherine N. de la Torre, Beatriz G. Govender, Thavendran Kruger, Hendrik G. El-Faham, Ayman Albericio, Fernando |
author_sort | Jad, Yahya E. |
collection | PubMed |
description | Here we describe two novel uronium salts, TOMBU and COMBU, derived from the recently described Oxyma-B for use in peptide bond synthesis. These coupling reagents are more stable than COMU in DMF. Furthermore, using various peptide synthetic models in solution and solid-phase synthesis, we reveal that they show better performance than HBTU in terms of preserving chiral integrity and coupling yields, but slightly worse performance than COMU. |
format | Online Article Text |
id | pubmed-6271478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62714782019-01-07 TOMBU and COMBU as Novel Uronium-Type Peptide Coupling Reagents Derived from Oxyma-B Jad, Yahya E. Khattab, Sherine N. de la Torre, Beatriz G. Govender, Thavendran Kruger, Hendrik G. El-Faham, Ayman Albericio, Fernando Molecules Article Here we describe two novel uronium salts, TOMBU and COMBU, derived from the recently described Oxyma-B for use in peptide bond synthesis. These coupling reagents are more stable than COMU in DMF. Furthermore, using various peptide synthetic models in solution and solid-phase synthesis, we reveal that they show better performance than HBTU in terms of preserving chiral integrity and coupling yields, but slightly worse performance than COMU. MDPI 2014-11-18 /pmc/articles/PMC6271478/ /pubmed/25412042 http://dx.doi.org/10.3390/molecules191118953 Text en © 2014 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jad, Yahya E. Khattab, Sherine N. de la Torre, Beatriz G. Govender, Thavendran Kruger, Hendrik G. El-Faham, Ayman Albericio, Fernando TOMBU and COMBU as Novel Uronium-Type Peptide Coupling Reagents Derived from Oxyma-B |
title | TOMBU and COMBU as Novel Uronium-Type Peptide Coupling Reagents Derived from Oxyma-B |
title_full | TOMBU and COMBU as Novel Uronium-Type Peptide Coupling Reagents Derived from Oxyma-B |
title_fullStr | TOMBU and COMBU as Novel Uronium-Type Peptide Coupling Reagents Derived from Oxyma-B |
title_full_unstemmed | TOMBU and COMBU as Novel Uronium-Type Peptide Coupling Reagents Derived from Oxyma-B |
title_short | TOMBU and COMBU as Novel Uronium-Type Peptide Coupling Reagents Derived from Oxyma-B |
title_sort | tombu and combu as novel uronium-type peptide coupling reagents derived from oxyma-b |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271478/ https://www.ncbi.nlm.nih.gov/pubmed/25412042 http://dx.doi.org/10.3390/molecules191118953 |
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