Preparation of 2'-(13)C-L-Histidine Starting from (13)C-Thiocyanate: Synthetic Access to Any Site-Directed Stable Isotope Enriched L-Histidine

1-Benzyl-2-(methylthio)-imidazole-5-ketone is obtained in a few simple steps starting from thiocyanate and glycine amide (glycin). Subsequent treatment with diethyl phosphorocyanidate and functional group manipulations gives 1-benzyl-5-chloromethyl-imidazolium chloride. This compound is converted un...

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Detalles Bibliográficos
Autores principales: Talab, Sarra, Taha, Kamal Khalifa, Lugtenburg, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271553/
https://www.ncbi.nlm.nih.gov/pubmed/24434674
http://dx.doi.org/10.3390/molecules19011023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271553/
https://www.ncbi.nlm.nih.gov/pubmed/24434674
http://dx.doi.org/10.3390/molecules19011023

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