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Preparation of 2'-(13)C-L-Histidine Starting from (13)C-Thiocyanate: Synthetic Access to Any Site-Directed Stable Isotope Enriched L-Histidine
1-Benzyl-2-(methylthio)-imidazole-5-ketone is obtained in a few simple steps starting from thiocyanate and glycine amide (glycin). Subsequent treatment with diethyl phosphorocyanidate and functional group manipulations gives 1-benzyl-5-chloromethyl-imidazolium chloride. This compound is converted un...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271553/ https://www.ncbi.nlm.nih.gov/pubmed/24434674 http://dx.doi.org/10.3390/molecules19011023 |