Synthesis and Biological Evaluation of Substituted Desloratadines as Potent Arginine Vasopressin V2 Receptor Antagonists

Twenty-one non-peptide substituted desloratadine class compounds were synthesized as novel arginine vasopressin receptor antagonists from desloratadine via successive acylation, reduction and acylation reactions. Their structures were characterized by (1)H-NMR and HRMS, their biological activity was...

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Detalles Bibliográficos
Autores principales: Mu, Shuai, Liu, Ying, Gong, Min, Liu, Deng-Ke, Liu, Chang-Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271649/
https://www.ncbi.nlm.nih.gov/pubmed/24566331
http://dx.doi.org/10.3390/molecules19022694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271649/
https://www.ncbi.nlm.nih.gov/pubmed/24566331
http://dx.doi.org/10.3390/molecules19022694

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