Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase

Nicotinamide adenine dinucleotide (NAD), one of the most important coenzymes in the cells, is a substrate of the signaling enzyme CD38, by which NAD is converted to a second messenger, cyclic ADP-ribose, which releases calcium from intracellular calcium stores. Starting with 2′-deoxy-2′-fluoroarabin...

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Detalles Bibliográficos
Autores principales: Wang, Shengjun, Zhu, Wenjie, Wang, Xuan, Li, Jianguo, Zhang, Kehui, Zhang, Liangren, Zhao, Yong-Juan, Lee, Hon Cheung, Zhang, Lihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271716/
https://www.ncbi.nlm.nih.gov/pubmed/25268725
http://dx.doi.org/10.3390/molecules191015754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271716/
https://www.ncbi.nlm.nih.gov/pubmed/25268725
http://dx.doi.org/10.3390/molecules191015754

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