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Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase

Nicotinamide adenine dinucleotide (NAD), one of the most important coenzymes in the cells, is a substrate of the signaling enzyme CD38, by which NAD is converted to a second messenger, cyclic ADP-ribose, which releases calcium from intracellular calcium stores. Starting with 2′-deoxy-2′-fluoroarabin...

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Detalles Bibliográficos
Autores principales:	Wang, Shengjun, Zhu, Wenjie, Wang, Xuan, Li, Jianguo, Zhang, Kehui, Zhang, Liangren, Zhao, Yong-Juan, Lee, Hon Cheung, Zhang, Lihe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271716/ https://www.ncbi.nlm.nih.gov/pubmed/25268725 http://dx.doi.org/10.3390/molecules191015754

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