Cargando…

RNA/aTNA Chimeras: RNAi Effects and Nucleases Resistance of Single and Double Stranded RNAs

The RNA interference pathway (RNAi) is a specific and powerful biological process, triggered by small non-coding RNA molecules and involved in gene expression regulation. In this work, we explored the possibility of increasing the biological stability of these RNA molecules by replacing their natura...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alagia, Adele, Terrazas, Montserrat, Eritja, Ramon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271724/ https://www.ncbi.nlm.nih.gov/pubmed/25375332 http://dx.doi.org/10.3390/molecules191117872

Ejemplares similares

Modulation of the RNA Interference Activity Using Central Mismatched siRNAs and Acyclic Threoninol Nucleic Acids (aTNA) Units
por: Alagia, Adele, et al.
Publicado: (2015)

Rapid Chemical Ligation of DNA and Acyclic Threoninol Nucleic Acid (aTNA) for Effective Nonenzymatic Primer Extension
por: Okita, Hikari, et al.
Publicado: (2023)

Intrastrand backbone-nucleobase interactions stabilize unwound right-handed helical structures of heteroduplexes of L-aTNA/RNA and SNA/RNA
por: Kamiya, Yukiko, et al.
Publicado: (2020)

Covalent Strategies for Targeting Messenger and Non-Coding RNAs: An Updated Review on siRNA, miRNA and antimiR Conjugates
por: Grijalvo, Santiago, et al.
Publicado: (2018)

Structural basis for TNA synthesis by an engineered TNA polymerase
por: Chim, Nicholas, et al.
Publicado: (2017)

Identification and Characterization of a Double-Stranded RNA Degrading Nuclease Influencing RNAi Efficiency in the Rice Leaf Folder Cnaphalocrocis medinalis
por: Li, Jiajing, et al.
Publicado: (2022)

An in Vitro Selection System for TNA
por: Ichida, Justin K., et al.
Publicado: (2005)

Detecting RNA-protein proximity at DNA double-strand breaks using combined fluorescence in situ hybridization with proximity ligation assay
por: Alagia, Adele, et al.
Publicado: (2023)

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
por: Chanut, Pauline, et al.
Publicado: (2016)

A Phagocytic Route for Uptake of Double-Stranded RNA in RNAi
por: Rocha, João J. E., et al.
Publicado: (2011)

Overexpression of Nicotianamine Synthase (AtNAS1) Increases Iron Accumulation in the Tuber of Potato
por: Zha, Manrong, et al.
Publicado: (2022)

Special Issue “Frontiers in Nucleic Acid Chemistry—In Memory of Professor Enrique Pedroso for His Outstanding Contributions to Nucleic Acid Chemistry”
por: Terrazas, Montserrat, et al.
Publicado: (2023)

Corrigendum: Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
por: Chanut, Pauline, et al.
Publicado: (2017)

Use of S1 nuclease in deep sequencing for detection of double-stranded RNA viruses
por: SHIMADA, Saya, et al.
Publicado: (2015)

Oral Delivery of Double-Stranded RNAs and siRNAs Induces RNAi Effects in the Potato/Tomato Psyllid, Bactericerca cockerelli
por: Wuriyanghan, Hada, et al.
Publicado: (2011)

High fidelity TNA synthesis by Therminator polymerase
por: Ichida, Justin K., et al.
Publicado: (2005)

In Vitro Selection of an ATP-Binding TNA Aptamer
por: Zhang, Li, et al.
Publicado: (2020)

Methoxymethyl Threofuranosyl Thymidine (4′-MOM-TNA-T) at the T7 Position of the Thrombin-Binding Aptamer Boosts Anticoagulation Activity, Thermal Stability, and Nuclease Resistance
por: Varada, Manojkumar, et al.
Publicado: (2019)

A New Cr(3+) Electrochemical Sensor Based on ATNA/Nafion/Glassy Carbon Electrode
por: El-Shishtawy, Reda M., et al.
Publicado: (2020)

Molecular Characterizations of Double-Stranded RNA Degrading Nuclease Genes from Ostrinia nubilalis
por: Cooper, Anastasia M. W., et al.
Publicado: (2020)

Properties of short double-stranded RNAs carrying randomized base pairs: toward better controls for RNAi experiments
por: Zagalak, Julian A., et al.
Publicado: (2015)

Kukoto tna'a-o : ichi iin nuú nii ja kukototna'a-o /
por: González Dillon, Mónica
Publicado: (2013)

Asymmetrically designed siRNAs and shRNAs enhance the strand specificity and efficacy in RNAi
por: Ding, Hongliu, et al.
Publicado: (2007)

Quantitative telomeric overhang determination using a double-strand specific nuclease
por: Zhao, Yong, et al.
Publicado: (2008)

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
por: Frock, Richard L., et al.
Publicado: (2014)

Kinetic Analysis of an Efficient DNA-Dependent TNA Polymerase
por: Horhota, Allen, et al.
Publicado: (2005)

DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation
por: Ketley, Ruth F., et al.
Publicado: (2022)

Double-stranded RNA binding protein, Staufen, is required for the initiation of RNAi in coleopteran insects
por: Yoon, June-Sun, et al.
Publicado: (2018)

Use of the HPRT gene to study nuclease-induced DNA double-strand break repair
por: Gravells, Polly, et al.
Publicado: (2015)

Precise therapeutic gene correction by a simple nuclease-induced double-strand break
por: Iyer, Sukanya, et al.
Publicado: (2019)

RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure
por: Allison, Simon J, et al.
Publicado: (2014)

Recombinational Repair of Nuclease-Generated Mitotic Double-Strand Breaks with Different End Structures in Yeast
por: Gamble, Dionna, et al.
Publicado: (2020)

Synthesis and polymerase activity of a fluorescent cytidine TNA triphosphate analogue
por: Mei, Hui, et al.
Publicado: (2017)

Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling
por: van der Stel, Anne-Xander, et al.
Publicado: (2021)

Cloning and Functional Characterization of a Double-Stranded RNA-Degrading Nuclease in the Tawny Crazy Ant (Nylanderia fulva)
por: Lei, Jiaxin, et al.
Publicado: (2022)

Persistent Parental RNAi in the Beetle Tribolium castaneum Involves Maternal Transmission of Long Double‐Stranded RNA
por: Horn, Thorsten, et al.
Publicado: (2022)

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
por: Toh, Desiree-Faye Kaixin, et al.
Publicado: (2017)

Methylation-sensitive enrichment of minor DNA alleles using a double-strand DNA-specific nuclease
por: Liu, Yibin, et al.
Publicado: (2017)

Aminoglycoside Interactions with RNAs and Nucleases
por: Kirsebom, L.A., et al.
Publicado: (2006)

Exploring PAZ/3′-overhang interaction to improve siRNA specificity. A combined experimental and modeling study
por: Alagia, Adele, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5ed0o4u911j1cadhiohmtgm5g8