Roles of Intramolecular and Intermolecular Hydrogen Bonding in a Three-Water-Assisted Mechanism of Succinimide Formation from Aspartic Acid Residues

Aspartic acid (Asp) residues in peptides and proteins are prone to isomerization to the β-form and racemization via a five-membered succinimide intermediate. These nonenzymatic reactions have relevance to aging and age-related diseases. In this paper, we report a three water molecule-assisted, six-s...

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Detalles Bibliográficos
Autores principales: Takahashi, Ohgi, Kirikoshi, Ryota, Manabe, Noriyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271739/
https://www.ncbi.nlm.nih.gov/pubmed/25093984
http://dx.doi.org/10.3390/molecules190811440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271739/
https://www.ncbi.nlm.nih.gov/pubmed/25093984
http://dx.doi.org/10.3390/molecules190811440

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