Design and Synthesis of New Cholesterol-Conjugated 5-Fluorouracil: A Novel Potential Delivery System for Cancer Treatment

Cholesterol-conjugated 5-fluorouracil prodrugs were designed to be carried in vivo via low density lipoproteins (LDL) and subsequently undergo LDL-receptor-mediated internalisation into cancer cells. In vivo anti-cancer evaluation was performed using 5-fluorouracil-cholesterol conjugate in a mouse m...

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Detalles Bibliográficos
Autores principales: Radwan, Awwad A., Alanazi, Fares K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271816/
https://www.ncbi.nlm.nih.gov/pubmed/25162958
http://dx.doi.org/10.3390/molecules190913177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271816/
https://www.ncbi.nlm.nih.gov/pubmed/25162958
http://dx.doi.org/10.3390/molecules190913177

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