Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties

The synthesis of four novel platinum complexes, bearing N(6)-(6-amino-hexyl)adenosine or a 1,6-di(adenosin-N(6)-yl)-hexane respectively, as ligands of mono-functional cisplatin or monochloro(ethylendiamine)platinum(II), is reported. The chemistry exploits the high affinity of the charged platinum ce...

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Detalles Bibliográficos
Autores principales: D’Errico, Stefano, Oliviero, Giorgia, Borbone, Nicola, Piccialli, Vincenzo, Pinto, Brunella, De Falco, Francesca, Maiuri, Maria Chiara, Carnuccio, Rosa, Costantino, Valeria, Nici, Fabrizia, Piccialli, Gennaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271865/
https://www.ncbi.nlm.nih.gov/pubmed/24995920
http://dx.doi.org/10.3390/molecules19079339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271865/
https://www.ncbi.nlm.nih.gov/pubmed/24995920
http://dx.doi.org/10.3390/molecules19079339

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