Cargando…

Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties

The synthesis of four novel platinum complexes, bearing N(6)-(6-amino-hexyl)adenosine or a 1,6-di(adenosin-N(6)-yl)-hexane respectively, as ligands of mono-functional cisplatin or monochloro(ethylendiamine)platinum(II), is reported. The chemistry exploits the high affinity of the charged platinum ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	D’Errico, Stefano, Oliviero, Giorgia, Borbone, Nicola, Piccialli, Vincenzo, Pinto, Brunella, De Falco, Francesca, Maiuri, Maria Chiara, Carnuccio, Rosa, Costantino, Valeria, Nici, Fabrizia, Piccialli, Gennaro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271865/ https://www.ncbi.nlm.nih.gov/pubmed/24995920 http://dx.doi.org/10.3390/molecules19079339

Ejemplares similares

Self‐Assembly of G‐Rich Oligonucleotides Incorporating a 3′–3′ Inversion of Polarity Site: A New Route Towards G‐Wire DNA Nanostructures
por: Oliviero, Giorgia, et al.
Publicado: (2017)

Synthesis of cyclic N(1)-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells
por: Mahal, Ahmed, et al.
Publicado: (2015)

5-Amino-1-(2′,3′-O-isopropylidene-d-ribityl)-1H-imidazole-4-carboxamide: a crystal structure with Z′ = 4
por: Piccialli, Vincenzo, et al.
Publicado: (2017)

Synthesis of mixed-sequence oligonucleotides on mesoporous silicon: chemical strategies and material stability
por: Terracciano, Monica, et al.
Publicado: (2014)

Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose
por: D’Errico, Stefano, et al.
Publicado: (2011)

Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-ribityl or 4-Hydroxybutyl Chains in Place of the Ribose
por: D’Errico, Stefano, et al.
Publicado: (2013)

A Facile Synthesis of 5′-Fluoro-5′-deoxyacadesine (5′-F-AICAR): A Novel Non-phosphorylable AICAR Analogue
por: D’Errico, Stefano, et al.
Publicado: (2012)

Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs
por: D’Errico, Stefano, et al.
Publicado: (2018)

New G-Quadruplex-Forming Oligodeoxynucleotides Incorporating a Bifunctional Double-Ended Linker (DEL): Effects of DEL Size and ODNs Orientation on the Topology, Stability, and Molecularity of DEL-G-Quadruplexes
por: Marzano, Maria, et al.
Publicado: (2019)

New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca(2+)-Modulating Activity Isolated from Sea Urchin Eggs
por: D’Errico, Stefano, et al.
Publicado: (2019)

Exploitation of a Very Small Peptide Nucleic Acid as a New Inhibitor of miR-509-3p Involved in the Regulation of Cystic Fibrosis Disease-Gene Expression
por: Amato, Felice, et al.
Publicado: (2014)

Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses
por: Borbone, Nicola, et al.
Publicado: (2021)

Peptide Nucleic Acids as miRNA Target Protectors for the Treatment of Cystic Fibrosis
por: Zarrilli, Federica, et al.
Publicado: (2017)

Evaluation of an Analogue of the Marine ε-PLL Peptide as a Ligand of G-quadruplex DNA Structures
por: Marzano, Maria, et al.
Publicado: (2020)

Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era
por: Borbone, Nicola, et al.
Publicado: (2022)

Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex
por: D’Errico, Stefano, et al.
Publicado: (2020)

3β,6α-Diacetoxy-5,9α-dihydroxy-5α-cholest-7-en-11-one
por: Piccialli, Vincenzo, et al.
Publicado: (2013)

3β,6β-Diacetoxy-5,9α-dihydroxy-5α-cholest-7-en-11-one acetic acid 0.04-solvate
por: Piccialli, Vincenzo, et al.
Publicado: (2013)

Exploring the Parallel G-Quadruplex Nucleic Acid World: A Spectroscopic and Computational Investigation on the Binding of the c-myc Oncogene NHE III1 Region by the Phytochemical Polydatin
por: Greco, Francesca, et al.
Publicado: (2022)

Porous Silicon-Based Aptasensors: The Next Generation of Label-Free Devices for Health Monitoring
por: Terracciano, Monica, et al.
Publicado: (2019)

The Anti-Proliferative Effect of L-Carnosine Correlates with a Decreased Expression of Hypoxia Inducible Factor 1 alpha in Human Colon Cancer Cells
por: Iovine, Barbara, et al.
Publicado: (2014)

Isolation of a Bis-Iodurated Tetra-THF as a Trace Product from the Oxidation of Squalene with RuO(4) and Its Double Ring Expansion to a Novel bis-THF-bis-THP Compound
por: Piccialli, Vincenzo, et al.
Publicado: (2011)

Design, Synthesis and Characterization of Novel Co-Polymers Decorated with Peptides for the Selective Nanoparticle Transport across the Cerebral Endothelium
por: Falanga, Andrea P., et al.
Publicado: (2018)

d(CGGTGGT) forms an octameric parallel G-quadruplex via stacking of unusual G(:C):G(:C):G(:C):G(:C) octads
por: Borbone, Nicola, et al.
Publicado: (2011)

Exploring a peptide nucleic acid-based antisense approach for CD5 targeting in chronic lymphocytic leukemia
por: Cesaro, Elena, et al.
Publicado: (2022)

CD, UV, and In Silico Insights on the Effect of 1,3-Bis(1′-uracilyl)-2-propanone on Serum Albumin Structure
por: Greco, Francesca, et al.
Publicado: (2022)

Studies toward the Synthesis of Smenamide A, an Antiproliferative Metabolite from Smenospongia aurea: Total Synthesis of ent-Smenamide A and 16-epi-Smenamide A
por: Caso, Alessia, et al.
Publicado: (2017)

PNA-Based Graphene Oxide/Porous Silicon Hybrid Biosensor: Towards a Label-Free Optical Assay for Brugada Syndrome
por: Moretta, Rosalba, et al.
Publicado: (2020)

ZnO Tetrapods for Label-Free Optical Biosensing: Physicochemical Characterization and Functionalization Strategies
por: Terracciano, Monica, et al.
Publicado: (2023)

(3S,3aS,6R,6aR)-2-Oxohexahydrofuro[3,2-b]furan-3,6-diyl dibenzoate
por: Piccialli, Vincenzo, et al.
Publicado: (2013)

(3R,3aR,6R,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diyl dibenzoate
por: Piccialli, Vincenzo, et al.
Publicado: (2013)

Antiproliferative Activity of Mycalin A and Its Analogues on Human Skin Melanoma and Human Cervical Cancer Cells
por: Capasso, Domenica, et al.
Publicado: (2020)

Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes
por: Piccialli, Ilaria, et al.
Publicado: (2022)

Silver (I) N-Heterocyclic Carbene Complexes: A Winning and Broad Spectrum of Antimicrobial Properties
por: Prencipe, Filippo, et al.
Publicado: (2021)

Ruthenium Tetroxide and Perruthenate Chemistry. Recent Advances and Related Transformations Mediated by Other Transition Metal Oxo-species
por: Piccialli, Vincenzo
Publicado: (2014)

The new K(V)3.4 inhibitor BDS-I[1–8] as a potential pharmacological opportunity in Alzheimer’s disease therapy
por: Piccialli, Ilaria, et al.
Publicado: (2020)

Synthesis of Brominated Lactones Related to Mycalin A: Selective Antiproliferative Activity on Metastatic Melanoma Cells and Inhibition of the Cell Migration
por: Capasso, Domenica, et al.
Publicado: (2023)

Transcriptomics and Metabolomics Integration Reveals Redox-Dependent Metabolic Rewiring in Breast Cancer Cells
por: Bonanomi, Marcella, et al.
Publicado: (2021)

4,5-Diamino-3-[(E,E)-4-(4,5-diamino-4H-1,2,4-triazol-3-yl)buta-1,3-dienyl]-4H-1,2,4-triazol-1-ium chloride
por: Centore, Roberto, et al.
Publicado: (2013)

2-Cyano-5-({4-[N-methyl-N-(2-hydroxyethyl)amino] phenyl}diazenyl)pyridine
por: Centore, Roberto, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_49a5mfgf0c7mrp88a78bogd2iu