Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents

We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of...

Descripción completa

Detalles Bibliográficos
Autores principales: Gil, Ana, Pabón, Adriana, Galiano, Silvia, Burguete, Asunción, Pérez-Silanes, Silvia, Deharo, Eric, Monge, Antonio, Aldana, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271909/
https://www.ncbi.nlm.nih.gov/pubmed/24552985
http://dx.doi.org/10.3390/molecules19022166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271909/
https://www.ncbi.nlm.nih.gov/pubmed/24552985
http://dx.doi.org/10.3390/molecules19022166

Ejemplares similares