Synthesis and Biological Activity of Some Bile Acid-Based Camptothecin Analogues

In an effort to decrease the toxicity of camptothecin (CPT) and improve selectivity for hepatoma and colon cancer cells, bile acid groups were introduced into the CPT 20 or 10 positions, resulting in the preparation of sixteen novel CPT-bile acid analogues. The compounds in which a bile acid group w...

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Detalles Bibliográficos
Autores principales: Li, Xingnuo, Zhao, Tengfei, Cheng, Dongping, Chu, Chu, Tong, Shengqiang, Yan, Jizong, Li, Qing-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271966/
https://www.ncbi.nlm.nih.gov/pubmed/24662087
http://dx.doi.org/10.3390/molecules19033761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271966/
https://www.ncbi.nlm.nih.gov/pubmed/24662087
http://dx.doi.org/10.3390/molecules19033761

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