1H-2,3-Dihydroperimidine Derivatives: A New Class of Potent Protein Tyrosine Phosphatase 1B Inhibitors

A series of 1H-2,3-dihydroperimidine derivatives was designed, synthesized, and evaluated as a new class of inhibitors of protein tyrosine phosphatase 1B (PTP1B) with IC(50) values in the micromolar range. Compounds 46 and 49 showed submicromolar inhibitory activity against PTP1B, and good selectivi...

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Detalles Bibliográficos
Autores principales: Wang, Wen-Long, Yang, Dong-Lin, Gao, Li-Xin, Tang, Chun-Lan, Ma, Wei-Ping, Ye, Hui-Hua, Zhang, Si-Qi, Zhao, Ya-Nan, Xu, Hao-Jie, Hu, Zhao, Chen, Xia, Fan, Wen-Hua, Chen, Hai-Jun, Li, Jing-Ya, Nan, Fa-Jun, Li, Jia, Feng, Bainian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271978/
https://www.ncbi.nlm.nih.gov/pubmed/24366088
http://dx.doi.org/10.3390/molecules19010102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271978/
https://www.ncbi.nlm.nih.gov/pubmed/24366088
http://dx.doi.org/10.3390/molecules19010102

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