Cargando…

1H-2,3-Dihydroperimidine Derivatives: A New Class of Potent Protein Tyrosine Phosphatase 1B Inhibitors

A series of 1H-2,3-dihydroperimidine derivatives was designed, synthesized, and evaluated as a new class of inhibitors of protein tyrosine phosphatase 1B (PTP1B) with IC(50) values in the micromolar range. Compounds 46 and 49 showed submicromolar inhibitory activity against PTP1B, and good selectivi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Wen-Long, Yang, Dong-Lin, Gao, Li-Xin, Tang, Chun-Lan, Ma, Wei-Ping, Ye, Hui-Hua, Zhang, Si-Qi, Zhao, Ya-Nan, Xu, Hao-Jie, Hu, Zhao, Chen, Xia, Fan, Wen-Hua, Chen, Hai-Jun, Li, Jing-Ya, Nan, Fa-Jun, Li, Jia, Feng, Bainian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271978/ https://www.ncbi.nlm.nih.gov/pubmed/24366088 http://dx.doi.org/10.3390/molecules19010102

Ejemplares similares

Nano-γ-Al(2)O(3)/SbCl(5): an efficient catalyst for the synthesis of 2,3-dihydroperimidines
por: Bamoniri, Abdolhamid, et al.
Publicado: (2018)

A coumarin–dihydroperimidine dye as a fluorescent chemosensor for hypochlorite in 99% water
por: Shiraishi, Yasuhiro, et al.
Publicado: (2019)

T Cell Protein Tyrosine Phosphatase in Osteoimmunology
por: Wang, Ya-nan, et al.
Publicado: (2021)

T Cell Protein Tyrosine Phosphatase in Glucose Metabolism
por: Wang, Ya-nan, et al.
Publicado: (2021)

The role of tyrosine phosphatase Shp2 in spermatogonial differentiation and spermatocyte meiosis
por: Li, Yang, et al.
Publicado: (2019)

Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A
por: Wang, Wen-Long, et al.
Publicado: (2012)

New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne
por: Piao, Shu-Juan, et al.
Publicado: (2014)

The Potent Inhibitors of Protein Tyrosine Phosphatase 1B from the Fruits of Melaleuca leucadendron
por: Saifudin, Azis, et al.
Publicado: (2016)

Plasiatine, an Unprecedented Indole–Phenylpropanoid Hybrid from Plantago asiatica as a Potent Activator of the Nonreceptor Protein Tyrosine Phosphatase Shp2
por: Gao, Zhong-Hua, et al.
Publicado: (2016)

Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis
por: Su, Tung-Hung, et al.
Publicado: (2017)

Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells
por: Du, Zhao-dong, et al.
Publicado: (2015)

Determination of the molecular reach of the protein tyrosine phosphatase SHP-1
por: Clemens, Lara, et al.
Publicado: (2021)

Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson's Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo
por: Feng, Chien-Wei, et al.
Publicado: (2020)

Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site
por: Pan, Chang, et al.
Publicado: (2013)

Posttranscriptional Inhibition of Protein Tyrosine Phosphatase Nonreceptor Type 23 by Staphylococcal Nuclease and Tudor Domain Containing 1: Implications for Hepatocellular Carcinoma
por: Jariwala, Nidhi, et al.
Publicado: (2019)

Dual-specificity phosphatase 23 mediates GCM1 dephosphorylation and activation
por: Lin, Fang-Yu, et al.
Publicado: (2011)

Synthesis of 2-ethoxycarbonylthieno[2,3-b]quinolines in biomass-derived solvent γ-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B
por: Mu, Xu-Yang, et al.
Publicado: (2021)

The Mechanism of Allosteric Inhibition of Protein Tyrosine Phosphatase 1B
por: Li, Shuai, et al.
Publicado: (2014)

Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors
por: Qin, Ningbo, et al.
Publicado: (2018)

Pan-cancer analyses of classical protein tyrosine phosphatases and phosphatase-targeted therapy in cancer
por: Wang, Tao, et al.
Publicado: (2022)

Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B
por: Lu, Zhiyuan, et al.
Publicado: (2020)

Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer
por: Chen, I-Chien, et al.
Publicado: (2016)

The metal face of protein tyrosine phosphatase 1B()
por: Bellomo, Elisa, et al.
Publicado: (2016)

Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase
por: Markovics, Adrienn, et al.
Publicado: (2020)

Prediction and verification of novel peptide targets of protein tyrosine phosphatase 1B
por: Li, Xun, et al.
Publicado: (2016)

Porphyromonas gingivalis Tyrosine Phosphatase Php1 Promotes Community Development and Pathogenicity
por: Jung, Young-Jung, et al.
Publicado: (2019)

Phosphatase Wip1 in Immunity: An Overview and Update
por: Shen, Xiao-Fei, et al.
Publicado: (2017)

Role of Protein Tyrosine Phosphatase 1B Inhibitor in Early Brain Injury of Subarachnoid Hemorrhage in Mice
por: Zhang, Zhong-Hua, et al.
Publicado: (2023)

Protein Tyrosine Phosphatase 1B Deficiency Ameliorates Murine Experimental Colitis via the Expansion of Myeloid-Derived Suppressor Cells
por: Zhang, Jing, et al.
Publicado: (2013)

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
por: Wakuda, Yusuke, et al.
Publicado: (2006)

Activation of Hydrogen Peroxide to Peroxytetradecanoic Acid Is Responsible for Potent Inhibition of Protein Tyrosine Phosphatase CD45
por: Kuban-Jankowska, Alicja, et al.
Publicado: (2012)

Genetic Variants in Protein Tyrosine Phosphatase Non-Receptor Type 23 Are Responsible for Mesiodens Formation
por: Adisornkanj, Ploy, et al.
Publicado: (2023)

Roles of protein tyrosine phosphatases in hepatocellular carcinoma progression (Review)
por: Chen, Yi-Li, et al.
Publicado: (2023)

A Polydnavirus Protein Tyrosine Phosphatase Negatively Regulates the Host Phenoloxidase Pathway
por: Gao, Hong-Shuai, et al.
Publicado: (2022)

New dammarane-type triterpenoids from the leaves of Panax notoginseng and their protein tyrosine phosphatase 1B inhibitory activity
por: Li, Dawei, et al.
Publicado: (2013)

Genetic alterations of protein tyrosine phosphatases in human cancers
por: Zhao, Shuliang, et al.
Publicado: (2014)

Protein tyrosine phosphatase 1B targets PITX1/p120RasGAP thus showing therapeutic potential in colorectal carcinoma
por: Teng, Hao-Wei, et al.
Publicado: (2016)

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor
por: Kim, Hyung-Gu, et al.
Publicado: (2013)

Protein tyrosine phosphatase L1 inhibits high-grade serous ovarian carcinoma progression by targeting IκBα
por: Wang, Yacheng, et al.
Publicado: (2018)

Identification of Phomoxanthone A and B as Protein Tyrosine Phosphatase Inhibitors
por: Yang, Runlei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0lbo9db6kq7s2nh9s0vnacueek