Drug-Induced Conformational Population Shifts in Topoisomerase-DNA Ternary Complexes

Type II topoisomerases (TOP2) are enzymes that resolve the topological problems during DNA replication and transcription by transiently cleaving both strands and forming a cleavage complex with the DNA. Several prominent anti-cancer agents inhibit TOP2 by stabilizing the cleavage complex and engende...

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Detalles Bibliográficos
Autores principales: Huang, Nan-Lan, Lin, Jung-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272011/
https://www.ncbi.nlm.nih.gov/pubmed/24905608
http://dx.doi.org/10.3390/molecules19067415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272011/
https://www.ncbi.nlm.nih.gov/pubmed/24905608
http://dx.doi.org/10.3390/molecules19067415

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