Cargando…

Drug-Induced Conformational Population Shifts in Topoisomerase-DNA Ternary Complexes

Type II topoisomerases (TOP2) are enzymes that resolve the topological problems during DNA replication and transcription by transiently cleaving both strands and forming a cleavage complex with the DNA. Several prominent anti-cancer agents inhibit TOP2 by stabilizing the cleavage complex and engende...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Nan-Lan, Lin, Jung-Hsin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272011/ https://www.ncbi.nlm.nih.gov/pubmed/24905608 http://dx.doi.org/10.3390/molecules19067415

Ejemplares similares

Recovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation
por: Huang, Nan-Lan, et al.
Publicado: (2015)

Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate
por: Chen, Shin-Fu, et al.
Publicado: (2018)

Evodiamine Stabilizes Topoisomerase I-DNA Cleavable Complex to Inhibit Topoisomerase I Activity
por: Chan, Agnes L.-F., et al.
Publicado: (2009)

Structural and Dynamical Effects Induced by the Anticancer Drug Topotecan on the Human Topoisomerase I – DNA Complex
por: Mancini, Giordano, et al.
Publicado: (2010)

DNA topoisomerases as molecular targets for anticancer drugs
por: Buzun, Kamila, et al.
Publicado: (2020)

Entrapment of DNA topoisomerase-DNA complexes by nucleotide/nucleoside analogs
por: Gmeiner, William H.
Publicado: (2019)

Immunodetection of human topoisomerase I-DNA covalent complexes
por: Patel, Anand G., et al.
Publicado: (2016)

Binding of an Indenoisoquinoline to the Topoisomerase-DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction
por: Mancini, Giordano, et al.
Publicado: (2012)

Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II
por: Lee, Ka C., et al.
Publicado: (2016)

DNA-Topology Simplification by Topoisomerases
por: Hanke, Andreas, et al.
Publicado: (2021)

Proteins of the origin recognition complex (ORC) and DNA topoisomerases on mammalian chromatin
por: Hu, Hong-gang, et al.
Publicado: (2009)

Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage
por: Das, Kalyan, et al.
Publicado: (2014)

Use of double-stranded DNA mini-circles to characterize the covalent topoisomerase-DNA complex
por: Millet, Armêl, et al.
Publicado: (2015)

Crystal structures of ternary complexes of archaeal B-family DNA polymerases
por: Kropp, Heike M., et al.
Publicado: (2017)

DNA topoisomerase I and II expression in drug resistantgerm cell tumours
por: Berney, D M, et al.
Publicado: (2002)

Expanding the type IIB DNA topoisomerase family: identification of new topoisomerase and topoisomerase-like proteins in mobile genetic elements
por: Takahashi, Diane T, et al.
Publicado: (2019)

Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage
por: Richter, Sara N., et al.
Publicado: (2006)

Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes
por: Tan, Yuliang, et al.
Publicado: (2023)

The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA–topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts
por: Dexheimer, Thomas S., et al.
Publicado: (2008)

DNA Topoisomerases Are Required for Preinitiation Complex Assembly during GAL Gene Activation
por: Roedgaard, Morten, et al.
Publicado: (2015)

Menogaril, an Anthracycline Derivative, Inhibits DNA Topoisomerase II by Stabilizing Cleavable Complexes
por: Ono, Katsuhiro, et al.
Publicado: (1992)

Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes
por: Jiang, Xiaohua, et al.
Publicado: (2023)

Correction to ‘Expanding the type IIB DNA topoisomerase family: identification of new topoisomerase and topoisomerase-like proteins in mobile genetic elements’
Publicado: (2022)

DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II
por: Gómez-Herreros, Fernando
Publicado: (2019)

Targeting DNA topoisomerases: past & future
por: Gmeiner, William H., et al.
Publicado: (2021)

Bacterial topoisomerase I and topoisomerase III relax supercoiled DNA via distinct pathways
por: Terekhova, Ksenia, et al.
Publicado: (2012)

Conformational plasticity of ligand-bound and ternary GPCR complexes studied by (19)F NMR of the β(1)-adrenergic receptor
por: Frei, J. Niclas, et al.
Publicado: (2020)

Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers
por: Pica, Andrea, et al.
Publicado: (2017)

Effects of DNA topoisomerase IIα splice variants on acquired drug resistance
por: Elton, Terry S., et al.
Publicado: (2020)

Altered stability of etoposide-induced topoisomerase II-DNA complexes in resistant human leukaemia K562 cells.
por: Ritke, M. K., et al.
Publicado: (1994)

A New Antitumor Agent Amrubicin Induces Cell Growth Inhibition by Stabilizing Topoisomerase II‐DNA Complex
por: Hanada, Mitsuharu, et al.
Publicado: (1998)

Correction to ‘Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage’
Publicado: (2022)

CFS-1686 Causes Cell Cycle Arrest at Intra-S Phase by Interference of Interaction of Topoisomerase 1 with DNA
por: Lin, Ru-Wei, et al.
Publicado: (2014)

Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes
por: Regairaz, Marie, et al.
Publicado: (2011)

Structures of topoisomerase V in complex with DNA reveal unusual DNA-binding mode and novel relaxation mechanism
por: Osterman, Amy, et al.
Publicado: (2022)

DNA Topoisomerase II Is Involved in Regulation of Cyst Wall Protein Genes and Differentiation in Giardia lamblia
por: Lin, Bo-Chi, et al.
Publicado: (2013)

Fluorescent Probes Detecting the Phagocytic Phase of Apoptosis: Enzyme-Substrate Complexes of Topoisomerase and DNA
por: Minchew, Candace L., et al.
Publicado: (2011)

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA
por: Lee, Ka Cheong, et al.
Publicado: (2012)

mSWI/SNF (BAF) Complexes Facilitate Decatentation of DNA by Topoisomerase IIα
por: Dykhuizen, Emily C., et al.
Publicado: (2013)

Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
por: Zhao, Bo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_sfcbheijarffju76v2n66tjag2