Highly Diastereoselective Synthesis of Spiropyrazolones

We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.

Detalles Bibliográficos
Autores principales: Ceban, Victor, Olomola, Temitope O., Meazza, Marta, Rios, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272153/
https://www.ncbi.nlm.nih.gov/pubmed/25985358
http://dx.doi.org/10.3390/molecules20058574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272153/
https://www.ncbi.nlm.nih.gov/pubmed/25985358
http://dx.doi.org/10.3390/molecules20058574

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