Highly Diastereoselective Synthesis of Spiropyrazolones

We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.

Detalles Bibliográficos
Autores principales: Ceban, Victor, Olomola, Temitope O., Meazza, Marta, Rios, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272153/
https://www.ncbi.nlm.nih.gov/pubmed/25985358
http://dx.doi.org/10.3390/molecules20058574
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author Ceban, Victor
Olomola, Temitope O.
Meazza, Marta
Rios, Ramon
author_facet Ceban, Victor
Olomola, Temitope O.
Meazza, Marta
Rios, Ramon
author_sort Ceban, Victor
collection PubMed
description We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.
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spelling pubmed-62721532019-01-07 Highly Diastereoselective Synthesis of Spiropyrazolones Ceban, Victor Olomola, Temitope O. Meazza, Marta Rios, Ramon Molecules Communication We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields. MDPI 2015-05-13 /pmc/articles/PMC6272153/ /pubmed/25985358 http://dx.doi.org/10.3390/molecules20058574 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Ceban, Victor
Olomola, Temitope O.
Meazza, Marta
Rios, Ramon
Highly Diastereoselective Synthesis of Spiropyrazolones
title Highly Diastereoselective Synthesis of Spiropyrazolones
title_full Highly Diastereoselective Synthesis of Spiropyrazolones
title_fullStr Highly Diastereoselective Synthesis of Spiropyrazolones
title_full_unstemmed Highly Diastereoselective Synthesis of Spiropyrazolones
title_short Highly Diastereoselective Synthesis of Spiropyrazolones
title_sort highly diastereoselective synthesis of spiropyrazolones
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272153/
https://www.ncbi.nlm.nih.gov/pubmed/25985358
http://dx.doi.org/10.3390/molecules20058574
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