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Highly Diastereoselective Synthesis of Spiropyrazolones

We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.

Detalles Bibliográficos
Autores principales:	Ceban, Victor, Olomola, Temitope O., Meazza, Marta, Rios, Ramon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272153/ https://www.ncbi.nlm.nih.gov/pubmed/25985358 http://dx.doi.org/10.3390/molecules20058574

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