Plasmin Regulation through Allosteric, Sulfated, Small Molecules

Plasmin, a key serine protease, plays a major role in clot lysis and extracellular matrix remodeling. Heparin, a natural polydisperse sulfated glycosaminoglycan, is known to allosterically modulate plasmin activity. No small allosteric inhibitor of plasmin has been discovered to date. We screened an...

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Detalles Bibliográficos
Autores principales: Al-Horani, Rami A., Karuturi, Rajesh, White, Domonique T., Desai, Umesh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272155/
https://www.ncbi.nlm.nih.gov/pubmed/25569517
http://dx.doi.org/10.3390/molecules20010608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272155/
https://www.ncbi.nlm.nih.gov/pubmed/25569517
http://dx.doi.org/10.3390/molecules20010608

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